KONFUMIN^®
(Sodium fumarate)

Pharmacological properties.

Pharmacodynamics. Active pharmaceutical ingredient of Konfumin is sodium fumarate. Sodium fumarate is an antihypoxant activating adaptation of the cells to oxygen deficiency. Its action is associated with participation in reversible oxidation-reduction reactions in the Krebs cycle. ATP synthesis, which is necessary to maintain body cell functions in hypoxia, occurs during these reactions. In case of oxygen deficiency, the pool of oxidation substrates, including fumarate ions, is exhausted, and its exogenous replenishing (injection as a part of Confumin) increases the reserve capacity of cellular respiration systems, allowing ATP synthesis by the cells under hypoxic conditions. These reactions provide the mechanism of antihypoxic action of Konfumin.

Maintaining the processes of oxidative metabolism in the tissues in case of oxygen deficiency prevents the formation and accumulation of unoxidized metabolic products, thereby reducing acidemia. Along with metabolic alkalization, Konfumin also contributes to weakening or eliminating of acidemia by chemical neutralization of acidic metabolic products. Sodium fumarate is a salt formed by a strong base and a weak acid. Once Konfumin is injected into the bloodstream, sodium fumarate undergoes hydrolysis to form fumaric acid and a strong base (NaOH). The latter is used for neutralization of acidic metabolic products, and fumaric acid is used for ATP synthesis.